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Prescribe ENTRESTO® to act directly on the heart and improve its structure and function1

Unbalanced, NPS and RAAS are 2 critical pathways that contribute to HFrEF and loss of pumping function2

Watch the mechanism of action video below to gain a deeper understanding of ENTRESTO’s complementary actions3



Discover how ENTRESTO can improve the heart’s structure and function, and reverse cardiac remodelling1,4,5

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ENTRESTO is indicated in adult patients for the treatment of symptomatic chronic heart failure with reduced ejection fraction.3

ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor neprilysin inhibitor; RAAS, renin-angiotensin-aldosterone system.


  1. Januzzi JL Jr, et al. JAMA 2019;322(11):1085–1095.
  2. Diez J et al. Eur J Heart Fail 2016; 19 (2) 167-176.
  3. ENTRESTO Summary of Product Characteristics. Accessed December 2021 at
  4. Desai AS, et al. JAMA 2019;322(11):1077–1084.
  5. Wang Y, et al. J Am Heart Assoc 2019;8(13):e012272.
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April 2022 | IE 171971

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Reporting of side effects
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk profile of the medicinal product. All suspected adverse reactions should be reported to HPRA Pharmacovigilance, website Adverse events can also be reported to Novartis preferably at, by emailing [email protected] or by calling (01) 2080 612.