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Cosentyx (secukinumab) in Rheumatology

Cosentyx is the first and only fully human targeted IL-17A inhibitor that offers fast and lasting relief from the signs and symptoms of PsA* and axSpA†‡

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Arrow with the text: Why Cosentyx in axSpA? Click image to find out mor

Arrow with the text: Can targeting IL-17A make the difference? Click image to find out more*

*Patients with PsA receiving Cosentyx achieved significant improvement in ACR20 vs placebo at Week 24: 54% Cosentyx300 mg s.c.; 51% 150 mg s.c. vs 15% placebo P<0.0001.2 This improvement was sustained after 5 years of treatment.3
Patients with AS receiving Cosentyx achieved significant improvement in ASAS20 vs placebo at Week 16: 61% Cosentyx 150 mg s.c. vs 28% placebo (P<0.001).5 This improvement was sustained after 5 years of treatment.6
Patients (NSAID-IR) with nr-axSpA receiving Cosentyx 150 mg s.c. vs placebo (N=555). Primary endpoint was met: ASAS40 at Week 16 and Week 52. ASAS40 vs placebo at Week 16: 42% Cosentyx 150 mg s.c. vs 29% placebo (P<0.05). This improvement was sustained after 1 year of treatment.7
δPatients with active AS receiving Cosentyx 150 mg (n=54 at Year 5).6
§Not limited to licensed indications.
**Across all licensed indications.

ACR, American College of Rheumatology; AS, ankylosing spondylitis; ASAS, Assessment in SpondyloArthritis international Society; axSpA, axial spondyloarthritis; BAD, British Association of Dermatologists; DMARD, disease-modifying antirheumatic drug; EULAR, European League Against Rheumatism IL, interleukin; ISR, injection site reaction; MRI, magnetic resonance imaging; nr-axSpA, non-radiographic axial spondyloarthritis; NSAID, non-steroidal anti-inflammatory drug; PsA, psoriatic arthritis; PsO, plaque psoriasis; s.c. subcutaneous; TB, tuberculosis.

  1. Cosentyx SmPC Available at www.medicines.ie last accessed March 2023
  2. McInnes IB et al. Lancet. 2015;386:1137–46.
  3. McInnes IB et al. Lancet Rheumatol. 2020;2:e227–35.
  4. Rheumatology DOF UK 102.
  5. Baeten D et al. N Engl J Med. 2015;373:2534–48.
  6. Marzo-Ortega H et al. Lancet Rheumatology. 2020;2:e339–46.
  7. Deodhar A et al. Arthritis Rheumatol. 2020 (epub ahead of print).
  8. Reich K et al. Br J Dermatol. 2019;181:954–66.
  9. Thaci D et al. J Am Acad Dermatol. 2015;73:400–9.
  10. Baraliakos X et al. Ann Rheum Dis. 2019;78. Abstract OP0235.
  11. McInnes IB et al. Lancet Rheumatol. 2020;2(4):e227-e235
  12. Baraliakos X et al. RMD Open. 2019;5(2):e001005.
  13. Braun J et al. Rheumatology (Oxford). 2019;58:859–68.
  14. Deodhar A et al. Ann Rheum Dis. 2020;79:722.
  15. Langley RG et al. N Engl J Med. 2014;371:326–38.
  16. McInnes IB et al. Lancet 2020;395:1496–505.
  17. Yiu Z et al. Br J Dermatol. 2020;183:294–302.
  18. Novartis Data on File. Secukinumab Cumulative Patient Numbers, Sec008. Feb 2023
  19. ClinicalTrials.gov. A study comparing AIN457 to placebo in subjects with a diagnosis of moderate to severe stable plaque psoriasis. https://clinicaltrials.gov/ct2/show/NCT00669916. Accessed 20 March 2023.
  20. Novartis Cosentyx® positive 16-week PREVENT results advance potential new indication for patients with axial spondyloarthritis [press release]. Basel, Switzerland. 17 September 2019. Novartis Cosentyx® positive 16-week PREVENT results advance potential new indication for patients with axial spondyloarthritis | Novartis Accessed 23 March 2023
  21. Novartis Q1 2022 Earnings. Available at: Q1 2022 Results (novartis.com) Accessed April 2022.
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IE271483 | March 2023
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Reporting of side effects
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk profile of the medicinal product. All suspected adverse reactions should be reported to HPRA Pharmacovigilance, website www.hpra.ie. Adverse events can also be reported to Novartis preferably at www.novartis.com/report, by emailing [email protected] or by calling (01) 2080 612.